Lipids are a class of compounds that are easily soluble in organic solvents,
mainly including fatty acids and their naturally occurring derivatives.
Their structures are heterogeneous and are closely related to life activities
and diseases in living organisms. Lipidomics analysis based on mass spectrometry
can reveal the metabolic regulation and physiological functions of lipids
and can help researchers understand the important mechanisms of lipids
in various life activities. Creative Proteomics has built an industry-recognized, state-of-the-art facility for the identification
and analysis of hundreds of lipids.
Creative Proteomics offers optimal sample pretreatment services for different
samples. The basic process for lipidomics analysis services is to first
perform lipid extraction on tissue, cell, or other types of samples. The
sample mixture will be divided into lipid and aqueous phases, and the lipid
phase will be analyzed by high-resolution LC-MS, LC-MS (MRM), and other
mass spectrometry facilities, and finally, the data will be analyzed and
identified by the combination of bioinformatics software and lipid database.
Mass spectrometry-based lipidomics analysis service can systematically
study the composition and content changes of lipids in organisms, reveal
their interactions and interactions with other biomolecules, to study the
mechanism of lipid metabolism regulation in various life phenomena. We
accept many types of samples, including but not limited to blood, tissue,
and cells.
The services we can provide are as follows.
Creative Proteomics utilizes different lipid extraction methods to extract
different kinds of lipids. Then, according to the difference in lipid polarity,
normal phase chromatography or reversed phase chromatography is adopted,
and then mass spectrometry is used to complete the identification of the
lipid group. This service enables the elucidation of how lipids are metabolized
and their mechanism of action.
The experimental accuracy of this service can reach 0.001–0.002
m/z. We can combine a variety of mass spectrometry techniques, such as
gas chromatography, atmospheric pressure ionization (API), and matrix-assisted
laser desorption ionization (MALDI), to complete the non-targeted analysis
of various lipids. In this way, you can study the physiological and pathological
changes of organisms through differences in lipid profiles.
In this service, we overcome the two problems of difficult lipid characterization
and excessive lipid detection data and can complete the targeted detection
of thousands of lipid substances at the same time. This will help you understand
the structure and function of lipids and explore the regulation of lipids
on physiological and pathological states of the body.
Creative Proteomics, a leader in mass spectrometry-based analysis services, can provide you
with comprehensive and customizable mass spectrometry-based lipidomics
analysis services. If you are interested, please feel free to contact us.
The service is for research only, not for clinical use.
