The mass spectrometry team at Creative Proteomic has a unique insight into the measurement service of tandem mass spectrometry (MS/MS or MSn) and can provide you with customized MS/MS or MSn solutions to overcome the problems you encounter in your research projects.
Tandem mass spectrometry is a technique with higher specificity, more accurate material characterization, and more sensitive quantitative analysis. TMS/MS or MSn is mainly composed of two mass spectrometers connected in series. The primary mass spectrometer separates the target sample according to different mass-to-charge ratios and performs energy modification on the sample. The secondary mass spectrometer detects the fragment ions after the collision between the sample and the inert gas. The mass-to-charge ratio is measured for qualitative and quantitative analysis of the sample. The excellent performance and reliability of MS/MS or MSn make it widely used in many fields.
Service Content of Measurement of MS/MS or MSn
Creative Proteomics performs tandem mass spectrometry by collision-induced dissociation (CID) or high-energy collisional dissociation (HCD). This technology is suitable for qualitative or quantitative analysis of target compounds in animal and plant samples, and can also be applied to detect drug metabolism. The data acquisition in tandem with mass spectrometry detection is completed by neutral particle loss, precursor ion scanning, and multiple reaction monitoring, and finally processed by professional data analysis software, which can meet the needs of portable and fully automatic detection.
Mass Spectrometry Facilities and Projects
- Bruker timsTOF Pro Mass Spectrometer
- Thermo Scientific™ UHPLC-Q Exactive Orbitrap Mass Spectrometer
- Thermo Scientific™ Orbitrap Fusion™ Tribrid™ Mass Spectrometer
- Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer
- Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap Mass Spectrometer
Requirements for Samples
- We focus on endogenous, microbial, and exogenous small molecules (< 2000 Da) in various matrices including cell lysates, tissues, and biological fluids (e.g., plasma, urine).
- Please contact us for specific sample requirements.
- Please provide the specific concentration, volume, preparation time, and source of each sample. And inform the sample information and control and experimental samples (if there are groups, describe the group analysis information in detail.).
Deliverables
- Experimental steps
- Relevant mass spectrometry parameters
- Details of the identified phosphorylation sites
- Mass spectrometry images
- Raw data
Applications of Measurement of MS/MS or MSn
- Food safety: qualitative and quantitative analysis of non-target compounds in food.
- Drug development: for product degradation, purity, and impurity studies in drug development.
- Chemical production: small molecule organic compounds, volatile components for mixed component separation and characterization, unknown component characterization, compound purity analysis, solvent residue analysis.
Service Process
Creative Proteomics has accumulated rich experience in tandem mass spectrometry, and can quickly and effectively solve all the problems you encounter in mass spectrometry analysis. If you are interested in our measurement service of MS/MS or MSn, please contact us today for details and a quote.
The service is for research only, not for clinical use.
